adenovirus expressing mutant HPV E6/E7

{
  "id": "MLC-T-ONC-009691",
  "term": "adenovirus expressing mutant HPV E6/E7",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine comprised of a genetically engineered, replication-deficient adenovirus encoding inactive, mutant forms of the human papillomavirus (HPV) transforming proteins E6 and E7, with potential immunostimulating and antineoplastic activities. Upon administration of adenovirus expressing mutant HPV E6/E7, the adenovirus infects and expresses the E6 and E7 proteins. The expressed E6 and E7 proteins stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing HPV E6 and E7, thereby inducing tumor cell lysis. Oncoproteins E6 and E7 play a key role in the development of cervical intraepithelial neoplasia (CIN) and cervical carcinoma.",
  "synonyms": [
    "Ad-E6E7",
    "Ad-E6/E7",
    "adenoviral-HPV E6E7 vaccine",
    "adenoviral-expressing mutant HPV E6/E7",
    "adenovirus vaccine expressing mutant HPV E6 and E7"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adenovirus-expressing-mutant-hpv-e6-e7/"
}