HPV 16/18 E6/E7 DNA vaccine pBI-11

{
  "id": "MLC-T-ONC-014177",
  "term": "HPV 16/18 E6/E7 DNA vaccine pBI-11",
  "field": "Oncology and biomedicine",
  "definition": "A therapeutic codon-optimized DNA vaccine encoding for the E6 and E7 proteins of human papillomavirus (HPV) subtypes 16 and 18, with potential immunostimulating and antineoplastic activities. Upon administration, the HPV 16/18 E6/E7 DNA vaccine pBI-11 expresses the HPV 16/18 E6/E7 fusion protein which may elicit a specific cytotoxic T-lymphocyte (CTL) response against cancer cells expressing the HPV 16/18 E6 and E7 oncoproteins, resulting in tumor cell lysis. HPV type 16 and 18 are the most common HPV types involved in cervical carcinogenesis. Codon optimization of the HPV16/18 E6/E7 genes in pBI-11 improves fusion protein expression.",
  "synonyms": [
    "DNA vaccine pBI-11",
    "E6/E7 DNA vaccine pBI-11"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hpv-16-18-e6-e7-dna-vaccine-pbi-11/"
}