Human adenovirus type 5 encoding HPV-16 E6/E7 vaccine IBRX-042

{
  "id": "MLC-T-ONC-014236",
  "term": "Human adenovirus type 5 encoding HPV-16 E6/E7 vaccine IBRX-042",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine composed of an adenovirus type 5 (Ad5) vector that encodes for the viral oncoproteins E6 and E7 derived from human papillomavirus serotype 16 (HPV-16; HPV16), with potential immunomodulating and antineoplastic activities. Upon administration, hAd5 encoding HPV-16 E6/E7 vaccine IBRX-042 induces expression of the HPV-16 E6/E7 proteins, which stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL)-mediated response against tumor cells expressing HPV-16 E6 and E7. Oncoproteins E6 and E7 play a key role in the development of various malignancies.",
  "synonyms": [
    "hAd5 encoding HPV16 E6/E7 vaccine IBRX-042",
    "hAd5-encoding HPV16 E6/E7 vaccine IBRX-042",
    "hAd5-HPV E6.ETSD-IRES-E7.ETSD vaccine IBRX-042"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/human-adenovirus-type-5-encoding-hpv-16-e6-e7-vaccine-ibrx-042/"
}