human anti-CD30 CAR-expressing autologous T-lymphocytes

{
  "id": "MLC-T-ONC-014237",
  "term": "human anti-CD30 CAR-expressing autologous T-lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) derived from a human anti-CD30 monoclonal antibody, with potential immunostimulating and antineoplastic activities. Upon administration, the human anti-CD30 CAR-expressing autologous T-lymphocytes specifically recognize and bind to CD30-expressing tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies. Compared to CAR-T cells that use murine scFv-based CARs, CAR-T cells containing CARs with human scFv regions reduces the immunogenicity of the CAR-T cells and may improve their longevity.",
  "synonyms": [
    "human anti-CD30 CAR-expressing autologous T-cells",
    "human anti-CD30scFv CAR-expressing autologous T-lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/human-anti-cd30-car-expressing-autologous-t-lymphocytes/"
}