Autologous CD30CAR-CD28-CD3zeta-expressing T lymphocytes

{
  "id": "MLC-T-ONC-011549",
  "term": "Autologous CD30CAR-CD28-CD3zeta-expressing T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes (ATL) that have been transduced with the retroviral vector SFG, a Moloney murine leukemia (Mo-MuLV) virus-based vector, encoding a chimeric antigen receptor (CAR) composed of a single chain single-chain variable fragment (scFv) directed against the CD30 antigen (CAR.CD30) and linked, via the spacer human IgG1 immunoglobulin heavy constant region (hinge-CH2CH3 region), to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous CD30CAR-CD28-CD3zeta-expressing T lymphocytes specifically recognize and bind to CD30-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies.",
  "synonyms": [
    "ATLCAR.CD30 cells",
    "ATLCAR.CD30-CD28zeta cells",
    "ATL-expressing CD30-CAR-CD28zeta",
    "anti-CD30-CAR/CD28z retroviral vector-transduced autologous T cells",
    "autologous CAR-CD19-CD28-zeta-transduced T lymphocytes",
    "CAR-CD30-28zeta-specific autologous T cells",
    "SFG.CAR.CD30 autologous T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cd30car-cd28-cd3zeta-expressing-t-lymphocytes/"
}