autologous anti-CD30 CAR T cells HSP-CAR30

{
  "id": "MLC-T-ONC-011397",
  "term": "autologous anti-CD30 CAR T cells HSP-CAR30",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the CD30 antigen, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD30 CAR T cells HSP-CAR30 specifically recognize and bind to CD30-expressing tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies.",
  "synonyms": [
    "autologous CD30-targeting CAR T cells HSP-CAR30"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd30-car-t-cells-hsp-car30/"
}