autologous anti-CD38 A2 CAR2-expressing T cells

{
  "id": "MLC-T-ONC-011398",
  "term": "autologous anti-CD38 A2 CAR2-expressing T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of genetically modified autologous T cells expressing a chimeric antigen receptor recognizing the tumor-associated antigen (TAA) cluster of differentiation 38 (CD38), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-CD38 A2 CAR2-expressing T cells are directed to and induce selective toxicity in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis.",
  "synonyms": [
    "autologous anti-CD38 A2 CAR2 T cells",
    "autologous CAR2 anti-CD38 A2 CAR T cells",
    "autologous CAR2 anti-CD38 A2 T lymphocytes",
    "autologous CD38-A2 CAR2-expressing T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd38-a2-car2-expressing-t-cells/"
}