anti-CD3/CD38 bispecific monoclonal antibody AMG 424

{
  "id": "MLC-T-ONC-010381",
  "term": "anti-CD3/CD38 bispecific monoclonal antibody AMG 424",
  "field": "Oncology and biomedicine",
  "definition": "A humanized, bispecific monoclonal antibody (BsAb) targeting CD3, a T-cell surface antigen, and CD38, a human cell surface glycoprotein and tumor-associated antigen (TAA), with potential antineoplastic activity. Upon intravenous administration, anti-CD3/CD38 bispecific monoclonal antibody AMG 424 binds to both CD3 on T cells and CD38 expressed on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis.",
  "synonyms": [
    "anti-CD3 x anti-CD38 bispecific monoclonal antibody AMG 424",
    "anti-CD3/anti-CD38 bispecific monoclonal antibody AMG 424",
    "CD3xCD38 BsAb AMG 424"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd3-cd38-bispecific-monoclonal-antibody-amg-424/"
}