anti-CD38/CD3 bispecific monoclonal antibody GBR 1342

{
  "id": "MLC-T-ONC-010365",
  "term": "anti-CD38/CD3 bispecific monoclonal antibody GBR 1342",
  "field": "Oncology and biomedicine",
  "definition": "A humanized, bispecific monoclonal antibody (BsAb) against human CD3, a T-cell surface antigen, and the human cell surface glycoprotein CD38, a tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, anti-CD38/anti-CD3 bispecific monoclonal antibody GBR 1342 binds to both CD3 on T cells and CD38 expressed on certain tumor cells. This results in the cross-linking of T cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis. GBR 1342 uses the proprietary bispecific engagement by antibodies based on the T-cell receptor (BEAT) platform.",
  "synonyms": [
    "anti-CD38/anti-CD3 bispecific monoclonal antibody GBR 1342",
    "anti-CD38 x anti-CD3 bispecific monoclonal antibody GBR 1342",
    "BEAT GBR 1342",
    "CD38xCD3 BsAb GBR 1342"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd38-cd3-bispecific-monoclonal-antibody-gbr-1342/"
}