anti-CD38/CD3 bispecific monoclonal antibody XmAb18968

{
  "id": "MLC-T-ONC-010366",
  "term": "anti-CD38/CD3 bispecific monoclonal antibody XmAb18968",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific monoclonal antibody targeting CD3, a T-cell surface antigen, and CD38, a human cell surface glycoprotein and tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, anti-CD3/CD38 bispecific monoclonal antibody XmAb18968 binds to both CD3 on T cells and CD38 expressed on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis.",
  "synonyms": [
    "CD3 x CD38 bispecific monoclonal antibody XmAb18968"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd38-cd3-bispecific-monoclonal-antibody-xmab18968/"
}