anti-CD3/CD19/CD20 trispecific antibody 1A46

{
  "id": "MLC-T-ONC-010380",
  "term": "anti-CD3/CD19/CD20 trispecific antibody 1A46",
  "field": "Oncology and biomedicine",
  "definition": "A trispecific immunoglobulin G (IgG)-like T-cell engaging antibody targeting the two tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19) and CD20, and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD3/CD19/CD20 trispecific antibody 1A46 binds to CD19- and/or CD20-expressing tumor B cell and CD3 antigen on cytotoxic T lymphocytes (CTLs). This activates and redirects CTLs to CD19- and/or CD20-expressing tumor cells, resulting in CTL-mediated killing of tumor cells. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD19 and CD20 may prevent tumor cell antigen escape and relapse.",
  "synonyms": [
    "anti-CD3/anti-CD19/anti-CD20 trispecific antibody 1A46",
    "anti-CD3/CD19/CD20 trispecific antibody CMG1A46",
    "CD19/CD20-targeting T-cell-engaging tri-specific antibody CMG1A46",
    "CD3/CD19/CD20 T-cell engager CMG1A46"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd3-cd19-cd20-trispecific-antibody-1a46/"
}