anti-CD20/anti-CD3/anti-CD8 trispecific antibody AZD5492

{
  "id": "MLC-T-ONC-010301",
  "term": "anti-CD20/anti-CD3/anti-CD8 trispecific antibody AZD5492",
  "field": "Oncology and biomedicine",
  "definition": "A trispecific immunoglobulin G (IgG)-like T-cell engaging (TCE) antibody targeting the tumor-associated antigen (TAA) CD20 and the T-cell surface antigens CD3 and CD8, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD20/anti-CD3/anti-CD8 trispecific antibody AZD5492 targets and binds to CD20 on CD20-expressing tumor B-cell, and the CD3 and CD8 antigens on CD8-positive T lymphocytes. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor cells. CD20, a B-cell-specific cell surface antigen, is overexpressed in B-cell lineage malignancies.",
  "synonyms": [
    "CD8/TCR-based CD20-targeting T-cell engaging antibody AZD5492",
    "T-cell engager AZD5492",
    "T-cell engaging antibody AZD5492",
    "TCE AZD5492",
    "triple-specific antibody AZD5492"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd20-anti-cd3-anti-cd8-trispecific-antibody-azd5492/"
}