anti-CD20/anti-CD3 bispecific antibody CM355

{
  "id": "MLC-T-ONC-010298",
  "term": "anti-CD20/anti-CD3 bispecific antibody CM355",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody and novel T-cell engager1 (nTCE) targeting both the tumor-associated antigen (TAA) CD20 and the CD3, a T-cell surface antigen, with potential immunomodulating and antineoplastic activities. Upon administration, anti-cd20/anti-cd3 bispecific antibody CM355 binds to both T cells and CD20-expressing B-lineage tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the CD20-expressing tumor B cells. CD20 is exclusively expressed on B cells during most stages of B-cell development and is often overexpressed in B-cell malignancies.",
  "synonyms": [
    "CD20xCD3 bispecific antibody CM355",
    "CD20/CD3 bispecific antibody CM355",
    "anti-CD20/CD3 bispecific antibody CM355"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd20-anti-cd3-bispecific-antibody-cm355/"
}