anti-DLL3/DLL3/CD3 trispecific antibody ZG006

{
  "id": "MLC-T-ONC-010579",
  "term": "anti-DLL3/DLL3/CD3 trispecific antibody ZG006",
  "field": "Oncology and biomedicine",
  "definition": "A trispecific T-cell engaging (TCE) antibody directed against two different epitopes of the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-DLL3/DLL3/CD3 trispecific antibody ZG006 binds to both the CD3 antigen on cytotoxic T lymphocytes (CTLs) and the DLL3 antigen on DLL3-expressing tumor cells. This activates and redirects CTLs to DLL3-expressing tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation.",
  "synonyms": [
    "DLL3 x DLL3 x CD3 trispecific antibody ZG006",
    "TCE antibody ZG006",
    "T-cell engaging antibody ZG006"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-dll3-dll3-cd3-trispecific-antibody-zg006/"
}