autologous anti-DLL-3 CAR-T cells LB2102

{
  "id": "MLC-T-ONC-011421",
  "term": "autologous anti-DLL-3 CAR-T cells LB2102",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) delta-like protein 3 (DLL3), with potential immunomodulating and antineoplastic activities. Upon administration, autologous anti-DLL3 CAR-T cells LB2102 recognize and induce selective toxicity in DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation.",
  "synonyms": [
    "autologous DLL3-directed CAR T cells LB2102",
    "autologous anti-DLL3 CAR T cells LB2102"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-dll-3-car-t-cells-lb2102/"
}