anti-DLL3 ADC ZL-1310

{
  "id": "MLC-T-ONC-010570",
  "term": "anti-DLL3 ADC ZL-1310",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) and linked to an as of yet unelucidated cytotoxic agent, with potential immunostimulating and antineoplastic activities. Upon administration, anti-DLL3 ADC ZL-1310 targets and binds to DLL3 found on DLL3-expressing tumor cells. Upon internalization, the cytotoxic agent causes cell death in DLL3-expressing tumor cells through an as of yet unknown mechanism of action. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation.",
  "synonyms": [
    "ADC SC-002",
    "anti-DLL3 antibody-drug conjugate ZL-1310"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-dll3-adc-zl-1310/"
}