anti-DLL3/CD3 bispecific antibody BI 764532

{
  "id": "MLC-T-ONC-010577",
  "term": "anti-DLL3/CD3 bispecific antibody BI 764532",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific T-cell engager antibody directed against both the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) and the CD3 antigen found on T lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-DLL3/CD3 bispecific antibody BI 764532 binds to both the CD3 antigen on cytotoxic T lymphocytes (CTLs) and the DLL3 antigen on DLL3-expressing tumor cells. This activates and redirects CTLs to DLL3-expressing tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation.",
  "synonyms": [
    "DLL3/CD3 bispecific antibody BI 764532",
    "T-cell engager BI 764532"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-dll3-cd3-bispecific-antibody-bi-764532/"
}