anti-DLL3 CAR-NK cells

{
  "id": "MLC-T-ONC-010574",
  "term": "anti-DLL3 CAR-NK cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) delta-like protein 3 (DLL3), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-DLL3 CAR-NK cells recognize, bind to and induce selective cytotoxicity in DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation.",
  "synonyms": [
    "DLL3-CAR-NK cells",
    "DLL3-CAR-natural killer cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-dll3-car-nk-cells/"
}