anti-EGFRvIII/CD3 bispecific antibody hEGFRvIII:CD3 bi-scFv

{
  "id": "MLC-T-ONC-010620",
  "term": "anti-EGFRvIII/CD3 bispecific antibody hEGFRvIII:CD3 bi-scFv",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody and T-cell engager composed of two single chain variable fragments (bi-scFvs) directed against both a mutant form of the human epidermal growth factor receptor (EGFR), EGFR variant III (EGFRvIII), and the epsilon subunit of the human T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-EGFRvIII/CD3 bispecific antibody hEGFRvIII:CD3 bi-scFv specifically binds to both CD3 on cytotoxic T lymphocytes (CTLs) and hEGFRvIII on hEGFRvIII-expressing tumor cells. This crosslinks T cells and tumor cells, and activates and redirects CTLs to hEGFRvIII-expressing tumor cells. This leads to CTL-mediated killing of hEGFRvIII-expressing tumor cells. hEGFRvIII, a mutant form of EGFR expressed in certain tumor cell types and frequently seen in malignant glioma, plays a key role in tumor cell proliferation and survival.",
  "synonyms": [
    "hEGFRvIII:CD3 bi-scFv",
    "BRiTE",
    "hEGFRvIII-CD3-bi-scFv bispecific T-cell engager"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-egfrviii-cd3-bispecific-antibody-hegfrviii-cd3-bi-scfv/"
}