anti-EGFRvIII/CD3 BiTE antibody AMG 596

{
  "id": "MLC-T-ONC-010622",
  "term": "anti-EGFRvIII/CD3 BiTE antibody AMG 596",
  "field": "Oncology and biomedicine",
  "definition": "A proprietary recombinant bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one that is directed against a tumor-associated antigen (TAA), the epidermal growth factor receptor (EGFR) deletion-mutant form, EGFR variant III (EGFRvIII), and one that is directed against the CD3 antigen found on T lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of anti-EGFRvIII/CD3 BiTE antibody AMG 596, the bispecific antibody binds to both the CD3 antigen on cytotoxic T lymphocytes (CTLs) and EGFRvIII found on EGFRvIII-expressing tumor cells. This activates and crosslinks CTLs with EGFRvIII-expressing tumor cells, which results in the CTL-mediated cell death of EGFRvIII-expressing tumor cells. EGFRvIII, a mutation in the EGFR gene where exons 2-7 have been deleted, is overexpressed by a variety of cancers, but is absent in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy.",
  "synonyms": [
    "anti-EGFRvIII x anti-CD3 bi-specific T-cell engager AMG 596",
    "bispecific BITE antibody AMG 596",
    "EGFRvIII specific BiTE antibody AMG 596",
    "BiTE antibody AMG 596"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-egfrviii-cd3-bite-antibody-amg-596/"
}