anti-EGFRvIII CAR-transduced allogeneic T lymphocytes

{
  "id": "MLC-T-ONC-010617",
  "term": "anti-EGFRvIII CAR-transduced allogeneic T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Allogeneic human T lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) variant III (EGFRvIII) mutant chimeric T-cell receptor (chimeric antigen receptor or CAR) gene coupled to the signaling domains from CD8, CD28, 4-1BB (CD137) and CD3 zeta, with potential immunostimulatory and antineoplastic activities. Upon administration, the anti-EGFRvIII CAR-transduced allogeneic T lymphocytes bind to the EGFRvIII antigen on tumor cell surfaces; subsequently, EGFRvIII-expressing tumor cells may be lysed. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types and absent in normal, healthy cells; it plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance.",
  "synonyms": [
    "anti-EGFRvIII CAR PG13-139-CD8-CD28BBZ-transduced T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-egfrviii-car-transduced-allogeneic-t-lymphocytes/"
}