EGFR CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes

{
  "id": "MLC-T-ONC-013239",
  "term": "EGFR CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) chimeric T cell receptor (chimeric antigen receptor or CAR) gene coupled to the signaling domains from both CD3 zeta and CD137 (4-1BB), with potential immunostimulatory and antineoplastic activities. Upon administration, the chimeric EGFR antigen receptor-modified autologous T lymphocytes bind to the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed. Following binding to EGFR, the 4-1BB co-stimulatory molecule signaling domain enhances both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase the antitumor activity when compared to the inclusion of the CD3-zeta chain alone. EGFR, a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, plays key roles in tumor cell proliferation and tumor angiogenesis.",
  "synonyms": [
    "CART-EGFR TCR zeta:CD1 27 cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/egfr-car-cd3zeta-4-1bb-expressing-autologous-t-lymphocytes/"
}