Autologous anti-CD19 CAR-CD3zeta-4-1BB-expressing T cells PZ01

{
  "id": "MLC-T-ONC-011362",
  "term": "Autologous anti-CD19 CAR-CD3zeta-4-1BB-expressing T cells PZ01",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19, coupled to the costimulatory domains of 4-1BB (CD137) and the zeta chain of the human T-cell receptor (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon transfusion, the autologous anti-CD19 CAR-CD3zeta-4-1BB-expressing T cells PZ01 target, bind to, and induce selective toxicity in CD19-expressing B cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies.",
  "synonyms": [
    "autologous CD19-specific CAR-T cells PZ01",
    "autologous PZ01 CAR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd19-car-cd3zeta-4-1bb-expressing-t-cells-pz01/"
}