anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing autologous T lymphocytes

{
  "id": "MLC-T-ONC-010270",
  "term": "anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous T lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 in tandem with an anti-CD20 scFv, and coupled to the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta), and the co-stimulatory molecule 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon transfusion, anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing autologous T lymphocytes recognize and direct T cells to CD19- or CD20-expressing tumor B cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19- or CD20-expressing tumor cells, and causes tumor cell lysis. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies.",
  "synonyms": [
    "autologous CAR-20/19-T cells",
    "anti-CD19/CD20 CAR autologous T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd19-cd20-car-cd3zeta-4-1bb-expressing-autologous-t-lymphocytes/"
}