RNA electroporated CD19CAR-CD3zeta-4-1BB-expressing autologous T lymphocytes

{
  "id": "MLC-T-ONC-016565",
  "term": "RNA electroporated CD19CAR-CD3zeta-4-1BB-expressing autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous, genetically engineered T lymphocytes that have been electroporated with an mRNA encoding for an anti-CD19 chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) coupled to the co-stimulatory signaling domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, the RNA electroporated CD19CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes attach to cancer cells expressing CD19. This induces selective toxicity against CD19-expressing tumor cells and causes tumor cell lysis. The 4-1BB co-stimulatory molecule signaling domain enhances T-cell activation and signaling after recognition of CD19. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies.",
  "synonyms": [
    "RNA anti-CD19 CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/rna-electroporated-cd19car-cd3zeta-4-1bb-expressing-autologous-t-lymphocytes/"
}