CD19CAR-CD3zeta-expressing autologous T lymphocytes

{
  "id": "MLC-T-ONC-012376",
  "term": "CD19CAR-CD3zeta-expressing autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous T lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD3zeta-expressing autologous T lymphocytes are directed to CD19-expressing tumor cells, thereby inducing a selective toxicity only in these tumor cells. The CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3-zeta (or CD247) is a transmembrane signaling adaptor polypeptide that regulates the assembly of complete T-cell receptor complexes and their expression on the cell surface.",
  "synonyms": [
    "autologous CART-19:TCR cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd19car-cd3zeta-expressing-autologous-t-lymphocytes/"
}