Tisagenlecleucel

{
  "id": "MLC-T-ONC-008721",
  "term": "Tisagenlecleucel",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat adults with certain types of B-cell non-Hodgkin lymphoma and people up to 25 years old with certain types of B-cell acute lymphoblastic leukemia. It is also being studied in the treatment of other types of cancer. Tisagenlecleucel is made using a patient’s T cells (a type of immune system cell). A gene for a special receptor called chimeric antigen receptor (CAR) is added to the T cells in the laboratory. These changed T cells called CAR T cells are grown in large numbers in the laboratory and given to the patient by infusion. Tisagenlecleucel binds to a protein called CD19, which is found on some leukemia and lymphoma cells. This helps the body’s immune system kill cancer cells. Tisagenlecleucel is a type of CAR T-cell therapy. Also called Kymriah.",
    "Autologous T lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities. Upon transfusion, tisagenlecleucel direct the T lymphocytes to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19 and the inclusion of this signaling domain may increase the antitumor activity compared to the inclusion of the CD3-zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3-zeta (or CD247) is a transmembrane signaling adaptor polypeptide that regulates the assembly of complete TCR complexes and their expression on the cell surface."
  ],
  "synonyms": [
    "Kymriah",
    "autologous CART-19 TCR:4-1BB cells",
    "CD19CAR-CD3zeta-4-1BB-expressing autologous T lymphocytes"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tisagenlecleucel/"
}