Autologous anti-CD19 CAR-4-1BB-CD3zeta-expressing T cells CNCT19

{
  "id": "MLC-T-ONC-011359",
  "term": "Autologous anti-CD19 CAR-4-1BB-CD3zeta-expressing T cells CNCT19",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that are engineered to express a chimeric antigen receptor (CAR) composed of an anti-cluster of differentiation 19 (CD19) single chain variable fragment (scFv) linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CD19 CAR-4-1BB-CD3zeta-expressing T cells CNCT19 target, bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.",
  "synonyms": [
    "autologous anti-CD19 CAR-T cells CNCT19"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd19-car-4-1bb-cd3zeta-expressing-t-cells-cnct19/"
}