Autologous anti-CD19 CAR TCR-zeta/4-1BB-transduced T lymphocytes huCART19

{
  "id": "MLC-T-ONC-011357",
  "term": "Autologous anti-CD19 CAR TCR-zeta/4-1BB-transduced T lymphocytes huCART19",
  "field": "Oncology and biomedicine",
  "definition": "Autologous T lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a humanized single chain variable fragment (scFv) of anti-CD19 coupled to the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta) and the co-stimulatory molecule 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon re-introduction into the patient, the autologous anti-CD19 CAR TCR-zeta/4-1BB-transduced T lymphocytes huCART19 target and bind to CD19-expressing neoplastic B cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, resulting in tumor cell lysis. CD19 (cluster of differentiation 19) is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of the co-stimulatory signaling domains increases human T-cell function, expansion, and survival.",
  "synonyms": [
    "autologous anti-CD19 CAR-CD3zeta-4-1BB-expressing T cells huCART19",
    "huCART19 cells",
    "huCART19 T lymphocytes",
    "anti-CD19 CAR-T cells huCART19",
    "CTL119 cells",
    "CTL119",
    "anti-CD19 Humanized scFv TCRz-41BB-CAR lentiviral vector-transduced autologous T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd19-car-tcr-zeta-4-1bb-transduced-t-lymphocytes-hucart19/"
}