Autologous anti-GFRa4 CAR-TCR-zeta-4-1BB-expressing T cells

{
  "id": "MLC-T-ONC-011436",
  "term": "Autologous anti-GFRa4 CAR-TCR-zeta-4-1BB-expressing T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of an anti-glial-derived neurotrophic factor (GDNF) family receptor alpha 4 (GFRa4) single chain variable fragment (scFv), coupled to the zeta chain of the human T-cell receptor (TCR/CD3zeta) and the co-stimulatory molecule 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon re-introduction into the patient, the autologous anti-GFRa4 CAR-TCR-zeta-4-1BB-expressing T cells target and bind to GFRa4-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against GFRa4-expressing tumor cells, resulting in tumor cell lysis. GFRa4 is highly expressed in metastatic medullary thyroid cancer (MTC) and also normally expressed in parafollicular cells within the thyroid and thymus.",
  "synonyms": [
    "CART-GFRa4 cells",
    "autologous GDNF family receptor alpha 4-targeted CAR-TCR-zeta-4-1BB-expressing T lymphocytes",
    "autologous anti-GFRa4 CAR-T cells",
    "autologous anti-GFRa4 CAR-CD3zeta-4-1BB-transduced T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-gfra4-car-tcr-zeta-4-1bb-expressing-t-cells/"
}