CD33CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes

{
  "id": "MLC-T-ONC-012395",
  "term": "CD33CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD33 scFv (single chain variable fragment) coupled to the signaling domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR retroviral vector-transduced autologous T lymphocytes target CD33-expressing tumor cells and induce selective toxicity in CD33-expressing tumor cells. Following binding to CD33, the 4-1BB co-stimulatory molecule signaling domain enhances both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase the antitumor activity when compared to the inclusion of the CD3-zeta chain alone. CD33 is expressed on normal non-pluripotent hematopoietic stem cells as well as on myeloid leukemia cells.",
  "synonyms": [
    "CART-33 TCR zeta:CD137 cells",
    "CART33 TCR zeta:CD137 cells",
    "anti-CD33 TCR zeta:CD137 CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd33car-cd3zeta-4-1bb-expressing-autologous-t-lymphocytes/"
}