Allogeneic CD33CAR-CD3zeta-4-1BB-expressing T lymphocytes

{
  "id": "MLC-T-ONC-009853",
  "term": "Allogeneic CD33CAR-CD3zeta-4-1BB-expressing T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic T lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the CD33 antigen, coupled to the signaling domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic CD33CAR-CD3zeta-4-1BB-expressing T lymphocytes target and induce selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells.",
  "synonyms": [
    "allogeneic anti-CD33 CAR-CD3zeta-4-1BB-expressing T cells",
    "allogeneic anti-CD33-CAR-CD3zeta-4-1BB-expressing T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-cd33car-cd3zeta-4-1bb-expressing-t-lymphocytes/"
}