anti-CD33 CAR T cells

{
  "id": "MLC-T-ONC-010340",
  "term": "anti-CD33 CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon administration, anti-CD33 CAR T cells specifically recognize and kill CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells.",
  "synonyms": [
    "anti-CD33 CAR-T cells",
    "CD33-CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd33-car-t-cells/"
}