allogeneic anti-CD33 CAR T cells VCAR33

{
  "id": "MLC-T-ONC-009818",
  "term": "allogeneic anti-CD33 CAR T cells VCAR33",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic T lymphocytes, derived from the same matched healthy donor who provided a stem cell transplant and transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic anti-CD33 CAR T cells VCAR33 specifically recognize and kill CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells.",
  "synonyms": [
    "allogeneic anti-CD33 CAR-T cells VCAR33",
    "donor-derived anti-CD33 CAR T cells VCAR33"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd33-car-t-cells-vcar33/"
}