autologous CLL1-CD33 compound CAR T cells

{
  "id": "MLC-T-ONC-011571",
  "term": "autologous CLL1-CD33 compound CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "Autologous T lymphocytes transduced with a lentiviral vector expressing a compound chimeric antigen receptor (cCAR) containing two CARs, one specific for the CD33 antigen and one specific for the C-type-lectin-like molecule-1 (CLL1; C-type lectin domain family 12 member A; CLEC12A), with potential immunomodulating and antineoplastic activities. Upon administration, the lentiviral vector-transduced autologous T lymphocytes, expressing both the anti-CD33 CAR and the anti-CLL1 CAR on their surfaces, specifically and simultaneously target and bind to CD33- and CLL1-expressing tumor cells, with their anti-CD33 CAR and their anti-CLL1 CAR, respectively. This induces selective toxicity in tumor cells that express the CD33 antigen and the CLL1 antigen. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells. CLL1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse for myeloid malignancies.",
  "synonyms": [
    "autologous CLL1-CD33 cCAR T cells",
    "autologous CLL1-CD33 cCAR",
    "autologous CLL1-CD33 cCAR T lymphocytes",
    "autologous anti-CLL1/anti-CD33 CARs-expressing T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cll1-cd33-compound-car-t-cells/"
}