CD33-specific CAR lentiviral vector-transduced autologous T lymphocytes

{
  "id": "MLC-T-ONC-012397",
  "term": "CD33-specific CAR lentiviral vector-transduced autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous T lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR lentiviral vector-transduced autologous T lymphocytes target and induce selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells.",
  "synonyms": [
    "autologous anti-CD33 CAR-T cells",
    "autologous CD33-CAR-T cells",
    "autologous anti-CD33 chimeric antigen receptor T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd33-specific-car-lentiviral-vector-transduced-autologous-t-lymphocytes/"
}