anti-CD33 antigen/CD3 receptor bispecific monoclonal antibody AMV564

{
  "id": "MLC-T-ONC-010339",
  "term": "anti-CD33 antigen/CD3 receptor bispecific monoclonal antibody AMV564",
  "field": "Oncology and biomedicine",
  "definition": "An anti-CD33/anti-CD3 bispecific tetravalent antibody, with potential immunostimulatory and antineoplastic activities. Anti-CD33/CD3 tetravalent bispecific monoclonal antibody AMV564 possesses two antigen-recognition and binding sites, one for the CD3 complex, a group of T-cell surface glycoproteins that complex with the T-cell receptor (TCR), and one for CD33, a tumor-associated antigen (TAA) overexpressed on the surface of a variety of tumor cell types. Upon infusion of AMV564, this bispecific antibody binds to CD3-expressing T cells and CD33-expressing tumor cells, thereby crosslinking CD33-expressing tumor cells and cytotoxic T-lymphocytes (CTLs). This may result in a potent CTL-mediated cell lysis of CD33-expressing cells. CD33, a glycoprotein expressed by a variety of cancers, including the majority of acute myeloid leukemias (AMLs), and normal non-pluripotent hematopoietic stem cells, plays a key role in tumor initiation, proliferation and progression.",
  "synonyms": [
    "CD33 x CD3 tandem diabody AMV-564",
    "CD33/CD3 TandAbs AMV564"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd33-antigen-cd3-receptor-bispecific-monoclonal-antibody-amv564/"
}