anti-CD33 monoclonal antibody-DM4 conjugate AVE9633

{
  "id": "MLC-T-ONC-010343",
  "term": "anti-CD33 monoclonal antibody-DM4 conjugate AVE9633",
  "field": "Oncology and biomedicine",
  "definition": "An immunoconjugate consisting of the humanized monoclonal antibody huMy9-6 conjugated to the cytotoxic maytansinoid DM4 with potential antineoplastic activity. The monoclonal antibody portion of anti-CD33 monoclonal antibody-DM4 conjugate AVE9633 specifically binds to the cell surface antigen CD33 expressed on myeloid leukemia cells; upon internalization, the DM4 moiety is released, binds tubulin, and disrupts microtubule assembly/disassembly dynamics, resulting in the inhibition of cell division and cell growth in myeloid leukemia cells that express CD33. CD33 is expressed on normal non-pluripotent hematopoietic stem cells as well as on myeloid leukemia cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd33-monoclonal-antibody-dm4-conjugate-ave9633/"
}