anti-integrin monoclonal antibody-DM4 immunoconjugate IMGN388

{
  "id": "MLC-T-ONC-010828",
  "term": "anti-integrin monoclonal antibody-DM4 immunoconjugate IMGN388",
  "field": "Oncology and biomedicine",
  "definition": "An immunoconjugate consisting of an anti-integrin monoclonal antibody covalently attached to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), with potential antineoplastic activity. Anti-integrin monoclonal antibody-DM4 immunoconjugate IMGN388 binds to tumor cell surface integrins; upon internalization, the DM4 moiety is released from the immunoconjugate, binding to tubulin and disrupting microtubule assembly/disassembly dynamics, which may result in inhibition of cell division and cell growth of integrin-expressing tumor cells. Integrins, a class of transmembrane cell surface receptors, link the extracellular matrix (ECM) to intracellular signaling pathways that control cell proliferation and differentiation.",
  "synonyms": [
    "integrin-targeted immunoconjugate IMGN388"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-integrin-monoclonal-antibody-dm4-immunoconjugate-imgn388/"
}