anti-PSMA monoclonal antibody MLN591-DM1 immunoconjugate MLN2704

{
  "id": "MLC-T-ONC-011051",
  "term": "anti-PSMA monoclonal antibody MLN591-DM1 immunoconjugate MLN2704",
  "field": "Oncology and biomedicine",
  "definition": "An immunoconjugate that consists of a humanized monoclonal antibody (MLN591), directed against prostate-specific membrane antigen linked to a maytansinoid (DM1). The monoclonal antibody moiety of MLN2704 binds to tumor cells expressing prostate-specific membrane antigen; MLN274 is then internalized into the tumor cell where the DM1 maytansinoid moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and cell death.",
  "synonyms": [
    "DM1-conjugated monoclonal antibody MLN591",
    "maytansinoid -1 conjugated with MLN591 monoclonal antibody"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-psma-monoclonal-antibody-mln591-dm1-immunoconjugate-mln2704/"
}