coltuximab ravtansine

{
  "id": "MLC-T-ONC-012710",
  "term": "coltuximab ravtansine",
  "field": "Oncology and biomedicine",
  "definition": "An immunoconjugate consisting of an anti-CD19 monoclonal antibody conjugated to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), with potential antineoplastic activity. Coltuximab ravtansine targets the cell surface antigen CD19, found on a number of B-cell-derived cancers. Upon antibody/antigen binding and internalization, the immunoconjugate releases DM4, which binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in inhibition of cell division and cell growth of CD19-expressing tumor cells.",
  "synonyms": [
    "anti-CD19-DM4 immunoconjugate SAR3419"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/coltuximab-ravtansine/"
}