anti-CA6-DM4 immunoconjugate SAR566658

{
  "id": "MLC-T-ONC-010192",
  "term": "anti-CA6-DM4 immunoconjugate SAR566658",
  "field": "Oncology and biomedicine",
  "definition": "An immunoconjugate consisting of a humanized monoclonal antibody against the tumor-associated sialoglycotope CA6 (huDS6) conjugated to the cytotoxic maytansinoid DM4, with potential antineoplastic activity. The anti-CA6 monoclonal antibody moiety of SAR566658 targets and binds to the cell surface antigen CA6. Upon antibody/antigen binding and internalization, the immunoconjugate releases DM4, which binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in inhibition of cell division and cell growth of CA6-expressing tumor cells. The CA6 epitope is found on a variety of solid tumors, including breast, ovarian, cervical, lung and pancreatic tumors.",
  "abbreviation": "huDs6-DM4",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ca6-dm4-immunoconjugate-sar566658/"
}