cantuzumab ravtansine

{
  "id": "MLC-T-ONC-012230",
  "term": "cantuzumab ravtansine",
  "field": "Oncology and biomedicine",
  "definition": "An immunotoxin of a humanized monoclonal antibody C242 (MoAb HuC242) conjugated to a derivative of the cytotoxic agent maytansine, DM4, with potential antitumor activity. Cantuzumab ravtansine is generated from MoAb C242, which is raised against a cell surface superantigen, CA242, found in a variety of human tumor cells. Upon binding and entry, the immunoconjugate releases the maytansinoid agent DM4, which binds to tubulin, thereby affecting microtubule assembly/disassembly dynamics. As a result, this agent prevents cell division and reduces cell growth of cancer cells that express CA242.",
  "synonyms": [
    "maytansinoid DM4-conjugated humanized monoclonal antibody huC242"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cantuzumab-ravtansine/"
}