anti-myeloma monoclonal antibody-DM4 immunoconjugate BT-062

{
  "id": "MLC-T-ONC-010911",
  "term": "anti-myeloma monoclonal antibody-DM4 immunoconjugate BT-062",
  "field": "Oncology and biomedicine",
  "definition": "An immunoconjugate consisting of a monoclonal antibody directed against a highly-expressed myleoma cell surface antigen covalently attached to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), with potential antineoplastic activity. Anti-myeloma monoclonal antibody-DM4 immunoconjugate BT-062 binds to an unspecified cell surface antigen highly expressed on myeloma cells; upon internaliization the DM4 moiety is released, binding to tubulin and disrupting microtubule assembly/disassembly dynamics, which may result in the inhibition of cell division and cell growth of myeloma tumor cells.",
  "synonyms": [
    "maytansinoid-conjugated anti-myeloma monoclonal antibody BT-062"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-myeloma-monoclonal-antibody-dm4-immunoconjugate-bt-062/"
}