anti-CA19-9 monoclonal antibody BNT321

{
  "id": "MLC-T-ONC-010191",
  "term": "anti-CA19-9 monoclonal antibody BNT321",
  "field": "Oncology and biomedicine",
  "definition": "A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the carbohydrate antigen sialyl Lewis A (carbohydrate antigen 19-9; CA19-9), with potential antineoplastic activity. Upon administration, anti-CA19-9 monoclonal antibody BNT321 targets and binds to CA19-9, and kills CA19-9-expressing tumor cells through the induction of both complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC). CA19-9 is overexpressed on a number of different tumor cell types, and plays a key role in tumor cell survival and metastasis.",
  "synonyms": [
    "HuMab-5B1",
    "HuMab 5B1",
    "anti-CA19-9 monoclonal antibody 5B1"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ca19-9-monoclonal-antibody-bnt321/"
}