anti-Lewis B/Lewis Y monoclonal antibody GNX102

{
  "id": "MLC-T-ONC-010859",
  "term": "anti-Lewis B/Lewis Y monoclonal antibody GNX102",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody directed against human tumor-associated carbohydrate antigens (TACAs) Lewis B (LeB) and Lewis Y (LeY), with potential antineoplastic activity. Upon administration, anti-LeB/LeY monoclonal antibody GNX102 binds to branched LeB and LeY glycans, which may induce an antibody-dependent cellular cytotoxicity (ADCC) response against LeB- and LeY-expressing tumor cells. LeB and LeY antigens, tetrasaccharides with low to moderate expression in monomeric form in normal adult tissues, is overexpressed in branched form in multiple forms of cancers.",
  "synonyms": [
    "anti-LeB/LeY monoclonal antibody GNX102",
    "anti-branched Lewis B/Lewis Y monoclonal antibody GNX102"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-lewis-b-lewis-y-monoclonal-antibody-gnx102/"
}