BR96-doxorubicin immunoconjugate

{
  "id": "MLC-T-ONC-012087",
  "term": "BR96-doxorubicin immunoconjugate",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate composed of the chimeric monoclonal antibody BR96 chemically linked to the cytotoxic drug doxorubicin. The antibody moiety of BMS-182248-1 binds to Lewis Y, a cell surface antigen expressed on many solid tumor types. Thus, the doxorubicin conjugate is targeted specifically to Lewis Y-expressing tumor cells, where it intercalates with DNA, thereby inhibiting DNA replication and repair, RNA synthesis and protein synthesis. (NCI)",
  "abbreviation": "BR96-DOX",
  "synonyms": [
    "BR96-DOX immunoconjugate",
    "BR96-doxorubicin",
    "BR96-doxorubicin conjugate",
    "cBR96-doxorubicin immunoconjugate"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/br96-doxorubicin-immunoconjugate/"
}