anti-LeY-CAR-transduced autologous T lymphocytes

{
  "id": "MLC-T-ONC-010860",
  "term": "anti-LeY-CAR-transduced autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Genetically modified, autologous T lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Lewis-Y (LeY), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, anti-LeY-CAR-transduced autologous T lymphocytes specifically target and induce selective toxicity in LeY-expressing tumor cells. LeY, a difucosylated carbohydrate antigen, is overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "LeY-targeted CAR-T cells",
    "LeY-targeted autologous CAR-T cells",
    "autologous-derived LeY-targeted CAR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ley-car-transduced-autologous-t-lymphocytes/"
}