anti-LGR5 monoclonal antibody BNC101

{
  "id": "MLC-T-ONC-010861",
  "term": "anti-LGR5 monoclonal antibody BNC101",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody targeting leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), with potential antineoplastic activity. Upon administration, the anti-LGR5 humanized monoclonal antibody BNC101 targets and binds to LGR5, thereby inhibiting LGR5-mediated signal transduction pathways. This prevents proliferation of LGR5-expressing tumor cells. LGR5, a member of the Wnt signaling pathway, is a cancer stem cell (CSC) receptor overexpressed on certain cancer cells; it plays a key role in CSC proliferation and survival.",
  "synonyms": [
    "ET-101"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-lgr5-monoclonal-antibody-bnc101/"
}