Autologous Anti-LGR5 CAR-T Cells CNA3103

{
  "id": "MLC-T-ONC-011465",
  "term": "Autologous Anti-LGR5 CAR-T Cells CNA3103",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T-lymphocytes transduced to express a chimeric antigen receptor (CAR) targeting the cancer stem cell (CSC) marker leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-LGR5 CAR-T cells CNA3103 selectively target, binds to and lyse LGR5-expressing tumor cells. LGR5, a member of the Wnt signaling pathway, is overexpressed on certain cancer cells; it plays a key role in CSC proliferation and survival, tumor initiation, growth, and metastasis. Its expression is linked to poor survival and poor patient response to therapy. CNA3103 contains the antigen-biding domain of the humanized monoclonal LGR5 antibody BNC101.",
  "synonyms": [
    "LGR5-targeted autologous CAR-T cells CNA3103",
    "leucine-rich repeat-containing G protein-coupled receptor 5-targeted autologous CAR T cells CNA3103",
    "Leucine-rich Repeat-containing G Protein-coupled Receptor 5-targeted Autologous CAR T-cells CNA3103"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-lgr5-car-t-cells-cna3103/"
}